If I had a cardboard box for a head I’d be sad too.  “Rumination refers to the tendency to repetitively think about the causes, situational factors, and consequences of one’s negative emotional experience. Basically, rumination means that you continuously think about the various aspects of situations that are upsetting. Think about your own tendencies. When Read More →

Abbreviations: BCM7: beta-casomorphin-7 FODMAP: fermentable Oligo-, Di- and Mono-saccharides and Polyols MCP1: monocyte chemotactic protein 1 MPO: myeloperoxidase NCGS: Non-celiac gluten sensitivity SIBO: small intestinal bacterial overgrowth   Today’s post is about an Italian trial confirming that all may not be right with the Western world’s favorite grain. The study is titled Small Amounts of Read More →

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  As long time readers of this blog know, I consider metabolic syndrome (insulin resistance, hypertension, cardiovascular disease, etc.) as fundamentally caused by translocating gut bacteria to the liver and systemic circulation. This explains what initiates what I’ve termed “The Inflammatory-Cortisol Ballet” and the metabolic consequences that flow from that. When it comes to heart Read More →

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  Welcome back from your second and last intermission. I trust the wait wasn’t too long. In today’s post, I’ll be concentrating on how cortisol is regulated by the body, and how these regulatory systems are shaped by immune activation. There is a happy medium where hormone concentrations within a defined lower and upper limit Read More →

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  Over the past year and a half, I’ve spent much my time on this blog detailing the various dietary practices and other conditions that can impair intestinal-barrier function, and for good reason. While our intestines are located within us, as far as the body is concerned, this environment is actually external to it. And Read More →

  The role of stress in negatively impacting the gastrointestinal system has long been recognized. It doesn’t take an Einstein to note a strong correlation between acute psychological stress and the onset of gut feelings that are anything but pleasant. I’ve written about how gut dysbiosis is capable of initiating psychological states like depression and Read More →

  Today I want to direct my readers’ attention to a review paper published in 2011, which explores the link between gut flora and both mental and skin health. I’ve already covered some of these mental-health topics here and here. It’s a sad commentary on medicine that the dermatologists who first proposed this connection between Read More →

  “Although genetic and biological factors play a major role in the development of obesity, hypertension, insulin resistance, and diabetes, these common disorders that are part of the metabolic syndrome are probably influenced by other factors. Evidence suggests that these disorders are mediated by a complex interplay between genetics, biology, and the environment. Stress, whether Read More →

  This is part two of my three-part series on insomnia. Today I want to cover how disease and inflammation cause sleep problems. In part one, I discussed some habits that help you get a good night’s sleep. And for a number of you who have occasional sleeplessness, improving your sleep hygiene is all that’s Read More →

  Today’s post covers how endotoxemia and a “leaky gut” negatively impact the hormonal or endocrine system known as the hypothalamic-pituitary-adrenal axis (HPA). The HPA axis is a negative-feedback circuit between the hypothalamus, the pituitary gland and the adrenals. Using hormones and the nervous system, these structures are in constant communication with one another to Read More →

  In the previous post, I talked about causes of small intestinal bacterial overgrowth (SIBO) due to compromised gastric barrier function. Today I want to talk about causes due to impaired intestinal movement or motility. But before I do so, I need to mention that being immune compromised predisposes to SIBO. Whether it’s due to Read More →

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