“Although genetic and biological factors play a major role in the development of obesity, hypertension, insulin resistance, and diabetes, these common disorders that are part of the metabolic syndrome are probably influenced by other factors. Evidence suggests that these disorders are mediated by a complex interplay between genetics, biology, and the environment. Stress, whether Read More →

  I want to continue my series on weight dysregulation by examining the role endotoxemia may play.  As you may have noticed, nowhere in the title does the word obesity appear. While I will talk about how gram-negative pathogens can promote weight gain, it’s equally clear that lipopolysaccharides (LPSs) derived from these same organisms can Read More →

  It should surprise none of you that I consider weight dysregulation one of the many manifestations of gut dysbiosis. Obesity is associated with a whole host of disorders, including type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver. Much of what I’ve written about endotoxemia also applies to obesity. This isn’t to say that Read More →

  In this fifth and final post on gut dysbiosis, endotoxemia and heart disease, I want to explore the role cholesterol plays in all of this. As you know, I consider cholesterol an innocent bystander in this piece, not the villain. So what is cholesterol? Cholesterol is an alcohol but not the same type of Read More →

    In this post, I discussed how unlikely it is that normal digestion of long-chain fatty acids is the source of the pathogens initiating arterial plaque formation. If anything, I showed how protective chylomicrons are in preventing just that. This then leaves us with increased intestinal permeability as the most likely source of translocating Read More →

  As promised, I want to discuss what role, if any, dietary fat plays in metabolic endotoxemia, especially in relation to cardiovascular disease. It appears from both animal and human studies that fat indeed increases the translocation of inflammatory lipopolysaccharides (LPS) from the gut into systemic circulation. What needs to be determined is whether all Read More →

  In the last, I told you how the consumption of gluten-grains is the number one dietary reason of constipation. However, it isn’t the only reason you may have trouble going to the bathroom. A number of people who are gluten-free have contacted me expressing frustration with their constipation. So what could be causing their Read More →

  In the last post I wrote about how beneficial bacteria shapes our immunity. Today I want to review some studies in children examining the association between gut dysbiosis and allergic diseases. As I’ve mentioned, commensal gut flora not only maintain the integrity of the gut wall preventing endotoxins and other antigens from entering systemic circulation, Read More →

  In this post, I want to talk about how your gut flora is an integral player in the development and health of your immune system. Up until now, I’ve talked about how a compromised gut-wall barrier can cause endotoxemia and other immune reactions via translocation of antigens into systemic circulation. However, maintaining gut wall Read More →

This is the third and last post in my series on insomnia. Today I want to talk about how diet can sabotage your chances of getting a good night’s sleep. Some of what follows will be glaringly obvious, but hopefully you’ll find something here that you didn’t know before. I’ll be dividing today’s post into Read More →