It should surprise none of you that I consider weight dysregulation one of the many manifestations of gut dysbiosis. Obesity is associated with a whole host of disorders, including type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver. Much of what I’ve written about endotoxemia also applies to obesity. This isn’t to say that Read More →

    In this post, I discussed how unlikely it is that normal digestion of long-chain fatty acids is the source of the pathogens initiating arterial plaque formation. If anything, I showed how protective chylomicrons are in preventing just that. This then leaves us with increased intestinal permeability as the most likely source of translocating Read More →

  As promised, I want to discuss what role, if any, dietary fat plays in metabolic endotoxemia, especially in relation to cardiovascular disease. It appears from both animal and human studies that fat indeed increases the translocation of inflammatory lipopolysaccharides (LPS) from the gut into systemic circulation. What needs to be determined is whether all Read More →

“We calculate that 99.99% (by weight) of the pesticides in the American diet are chemicals that plants produce to defend themselves….We estimate that Americans eat about 1.5g of natural pesticides per person per day, which is about 10,000 times more than they eat of synthetic pesticide residues.” From the paper Dietary pesticides (99.99% all natural) Read More →

This is the sixth post in my series on small intestinal bacterial overgrowth (SIBO). Today I want to talk about those dietary factors that cause impaired intestinal motility and inflammation. I was hoping to include my thoughts on plant lectins in this post, but once I realized I was closer to writing a small book Read More →

  This is the fifth post in the small intestinal bacterial overgrowth (SIBO) series. This and the next post deal with nutritional factors that predispose to SIBO. As I discussed here and here, there are a number of “non-dietary” causes of SIBO. Nevertheless, many of these diseases are clearly due to dietary factors, such as Read More →

  Small intestinal bacterial overgrowth (SIBO) is exactly what it sounds like, an overgrowth of pathogenic or harmful bacteria in the small intestine, and I think a lot of people are walking around with this medical condition but have no idea they have it. Partly because most people have never heard of it and partly Read More →

  In the previous two posts I wrote about the different types of gut flora and their physiological functions. In this post, I want to write about what can go terribly wrong when our commensal gut flora are unhappy. Let’s first define the term dysbiosis or disordered flora. I find that this term is thrown around Read More →

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