Today’s post highlights a research paper out of Italy published this past April. (1) The study compared fasting blood markers for the presence of zonulin, lipopolysaccharides (LPS) and the inflammatory immune protein CD14 between healthy 100-year-olds and two other groups: those under the age of 40 who had the misfortune of having suffered a heart attack Read More →

“Chronic low-grade inflammation is now considered to be a critical pathological factor underlying many modern chronic diseases, including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases, and is associated with aging. Chronic low-grade inflammation is characterized by elevated circulating levels of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, and IL-6. A primary cause Read More →

If I had a cardboard box for a head I’d be sad too.  “Rumination refers to the tendency to repetitively think about the causes, situational factors, and consequences of one’s negative emotional experience. Basically, rumination means that you continuously think about the various aspects of situations that are upsetting. Think about your own tendencies. When Read More →

Abbreviations: F-HFD: fructose enriched high-fat coconut oil diet F-SO-HFD: fructose enriched high-fat soybean oil diet HFD: high-fat coconut oil diet LPSs: lipopolysaccharides PUFAs: polyunsaturated fatty acids SO-HFD: high-fat soybean oil diet Viv: low-fat, high-fiber rodent diet   “Look! It’s moving. It’s sa — it’s… it’s alive. It’s alive… It’s alive, it’s moving, it’s alive! It’s Read More →

Abbreviations: CFU/mL: colony forming units per milliliter. ESS: euthyroid sick syndrome GI: gastrointestinal PPIs: proton-pump inhibitors SIBO: small intestinal bacterial overgrowth SIFBO: small intestinal fungal and bacterial overgrowth SIFO: small intestinal fungal overgrowth   Today I want to revisit two verified risk factors for small intestinal fungal and bacterial overgrowth (SIFBO). A study published in Read More →

Cheshire Cat: Where are you going? Alice: Which way should I go? Cheshire Cat: That depends on where you are going. Alice: I don’t know. Cheshire Cat: Then it doesn’t matter which way you go. ― Lewis Carroll, Alice in Wonderland   Dear Dr. Aaron E. Carroll, You don’t know me from Adam, but I feel Read More →

  Abbreviations: ATIs: amylase and trypsin enzyme inhibitors HFD: high-fat diet HPA axis: hypothalamic-pituitary-adrenal axis IAP: intestinal alkaline phosphatase (aka alkaline phosphatase) IL1-β: interleukin 1 beta LPSs: lipopolysaccharides NF-kB: nuclear factor kappa B PUFAs: polyunsaturated fatty acids TLRs: toll-like receptors TLR4: toll-like receptor 4 TNF-α: tumor necrosis factor alpha WGA: wheat germ agglutinin Today I Read More →

Dog-doing

  Today’s post will cover a meta-analysis (review) of randomized clinical trials that studied prebiotics and their effects on a host of different metabolic markers in humans. Published in the British Journal of Nutrition, this paper covered the results of twenty-six trials that collectively studied 831 subjects. (1) Studies included in this meta-analysis were restricted Read More →

Coronary

  As long time readers of this blog know, I consider metabolic syndrome (insulin resistance, hypertension, cardiovascular disease, etc.) as fundamentally caused by translocating gut bacteria to the liver and systemic circulation. This explains what initiates what I’ve termed “The Inflammatory-Cortisol Ballet” and the metabolic consequences that flow from that. When it comes to heart Read More →

Gluten

On February 13th of 2013, I published a post entitled Fibromyalgia, Irritable Bowel Syndrome and Endotoxemia. I made the case that the high prevalence of bowel dysfunction and fibromyalgia was no mere coincidence. In today’s post, I’ll present evidence from a preliminary study out of Spain implicating non-celiac gluten sensitivity (NCGS) as a possible trigger Read More →

Colon Anatomy

  This is a short post about an intriguing study done in rodents to assess what effect different polyunsaturated fatty acids (PUFAs) have on progression of ulcerative colitis (UC). (1) Ulcerative colitis is defined by Taber’s medical dictionary as: “An inflammatory bowel disease marked pathologically by continuous inflammation of the intestinal mucosa, which typically involves Read More →

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  Welcome back from your second and last intermission. I trust the wait wasn’t too long. In today’s post, I’ll be concentrating on how cortisol is regulated by the body, and how these regulatory systems are shaped by immune activation. There is a happy medium where hormone concentrations within a defined lower and upper limit Read More →

Dancer

  Welcome back from your intermission! It’s now time to begin act two of our inflammatory-cortisol ballet. In the first act we saw what happens when cortisol is low, as in adrenal insufficiency, and what occurs when cortisol is high, as in Cushing’s syndrome. But it’s now time to introduce the other members of our Read More →

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  Over the past year and a half, I’ve spent much my time on this blog detailing the various dietary practices and other conditions that can impair intestinal-barrier function, and for good reason. While our intestines are located within us, as far as the body is concerned, this environment is actually external to it. And Read More →

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  Abbreviations: BMI: body mass index FPG: fasting plasma glucose HbA1c: glycosylated hemoglobin hs-CRP: C-reactive protein IL-6: interleukin 6 IL-10: interleukin 10 IFN-y: interferon gamma LPSs: lipopolysaccharides SIFBO: small intestinal fungal and bacterial overgrowth TNF-a: tumor necrosis factor alpha Today’s post will review an interesting study out of Iran that was published in December (1). Read More →

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