Coronary

  As long time readers of this blog know, I consider metabolic syndrome (insulin resistance, hypertension, cardiovascular disease, etc.) as fundamentally caused by translocating gut bacteria to the liver and systemic circulation. This explains what initiates what I’ve termed “The Inflammatory-Cortisol Ballet” and the metabolic consequences that flow from that. When it comes to heart Read More →

Gluten

On February 13th of 2013, I published a post entitled Fibromyalgia, Irritable Bowel Syndrome and Endotoxemia. I made the case that the high prevalence of bowel dysfunction and fibromyalgia was no mere coincidence. In today’s post, I’ll present evidence from a preliminary study out of Spain implicating non-celiac gluten sensitivity (NCGS) as a possible trigger Read More →

Colon Anatomy

  This is a short post about an intriguing study done in rodents to assess what effect different polyunsaturated fatty acids (PUFAs) have on progression of ulcerative colitis (UC). (1) Ulcerative colitis is defined by Taber’s medical dictionary as: “An inflammatory bowel disease marked pathologically by continuous inflammation of the intestinal mucosa, which typically involves Read More →

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  Welcome back from your second and last intermission. I trust the wait wasn’t too long. In today’s post, I’ll be concentrating on how cortisol is regulated by the body, and how these regulatory systems are shaped by immune activation. There is a happy medium where hormone concentrations within a defined lower and upper limit Read More →

Dancer

  Welcome back from your intermission! It’s now time to begin act two of our inflammatory-cortisol ballet. In the first act we saw what happens when cortisol is low, as in adrenal insufficiency, and what occurs when cortisol is high, as in Cushing’s syndrome. But it’s now time to introduce the other members of our Read More →

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  Over the past year and a half, I’ve spent much my time on this blog detailing the various dietary practices and other conditions that can impair intestinal-barrier function, and for good reason. While our intestines are located within us, as far as the body is concerned, this environment is actually external to it. And Read More →

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  Abbreviations: BMI: body mass index FPG: fasting plasma glucose HbA1c: glycosylated hemoglobin hs-CRP: C-reactive protein IL-6: interleukin 6 IL-10: interleukin 10 IFN-y: interferon gamma LPSs: lipopolysaccharides SIFBO: small intestinal fungal and bacterial overgrowth TNF-a: tumor necrosis factor alpha Today’s post will review an interesting study out of Iran that was published in December (1). Read More →

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  “Proton-pump inhibitor therapy is now being prescribed for a wide variety of upper gastrointestinal symptoms on the basis that they might be acid induced and therefore may benefit from such treatment. This increasingly liberal usage of these powerful drugs is due to a number of factors, including reduced concerns about potential side effects, reduced Read More →

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  “Ignorance is preferable to error, and he is less remote from the truth who believes nothing than he who believes what is wrong.” Thomas Jefferson     Abbreviations: BCM7: beta-casomorphin-7 C. albicans: Candida albicans FOS: fructooligosaccharide GERD: gastroesophageal reflux disease GI: gastrointestinal H. pylori: Helicobacter pylori, aka Campylobacter pylori IBS: irritable bowel syndrome LES: Read More →

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  “We look for medicine to be an orderly field of knowledge and procedure. But it is not. It is an imperfect science, an enterprise of constantly changing knowledge, uncertain information, fallible individuals, and at the same time lives on the line. There is science in what we do, yes, but also habit, intuition, and Read More →

  “Saturated fats are benign with regard to inflammatory effects, as are the MUFAs [monounsaturated fats]. The meager effect that saturated fats have on serum cholesterol levels when modest but adequate amounts of polyunsaturated oils are included in the diet, and the lack of any clear evidence that saturated fats are promoting any of the Read More →

  The role of stress in negatively impacting the gastrointestinal system has long been recognized. It doesn’t take an Einstein to note a strong correlation between acute psychological stress and the onset of gut feelings that are anything but pleasant. I’ve written about how gut dysbiosis is capable of initiating psychological states like depression and Read More →