Abbreviations: ATIs: amylase and trypsin enzyme inhibitors HFD: high-fat diet HPA axis: hypothalamic-pituitary-adrenal axis IAP: intestinal alkaline phosphatase (aka alkaline phosphatase) IL1-β: interleukin 1 beta LPSs: lipopolysaccharides NF-kB: nuclear factor kappa B PUFAs: polyunsaturated fatty acids TLRs: toll-like receptors TLR4: toll-like receptor 4 TNF-α: tumor necrosis factor alpha WGA: wheat germ agglutinin Today I Read More →

Glass

  Abbreviations: CNS: central nervous system DNA: deoxyribonucleic acid DNMTs: DNA methyltranferases EAAT: excitatory amino acid transporter EAAT3: excitatory amino acid transporter 3 ENS: enteric nervous system FODMAP: Fermentable Oligo-, Di- and Mono-saccharides and Polyols GERD: gastroesophageal reflux disease GSH: glutathione IBS: irritable bowel syndrome LPSs: lipopolysaccharides SAM: S-adenosylmethionine SIFBO: small intestinal fungal and bacterial Read More →

Dog-doing

  Today’s post will cover a meta-analysis (review) of randomized clinical trials that studied prebiotics and their effects on a host of different metabolic markers in humans. Published in the British Journal of Nutrition, this paper covered the results of twenty-six trials that collectively studied 831 subjects. (1) Studies included in this meta-analysis were restricted Read More →

Gluten

On February 13th of 2013, I published a post entitled Fibromyalgia, Irritable Bowel Syndrome and Endotoxemia. I made the case that the high prevalence of bowel dysfunction and fibromyalgia was no mere coincidence. In today’s post, I’ll present evidence from a preliminary study out of Spain implicating non-celiac gluten sensitivity (NCGS) as a possible trigger Read More →

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  Abbreviations: BMI: body mass index FPG: fasting plasma glucose HbA1c: glycosylated hemoglobin hs-CRP: C-reactive protein IL-6: interleukin 6 IL-10: interleukin 10 IFN-y: interferon gamma LPSs: lipopolysaccharides SIFBO: small intestinal fungal and bacterial overgrowth TNF-a: tumor necrosis factor alpha Today’s post will review an interesting study out of Iran that was published in December (1). Read More →

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  “Ignorance is preferable to error, and he is less remote from the truth who believes nothing than he who believes what is wrong.” Thomas Jefferson     Abbreviations: BCM7: beta-casomorphin-7 C. albicans: Candida albicans FOS: fructooligosaccharide GERD: gastroesophageal reflux disease GI: gastrointestinal H. pylori: Helicobacter pylori, aka Campylobacter pylori IBS: irritable bowel syndrome LES: Read More →

  The role of stress in negatively impacting the gastrointestinal system has long been recognized. It doesn’t take an Einstein to note a strong correlation between acute psychological stress and the onset of gut feelings that are anything but pleasant. I’ve written about how gut dysbiosis is capable of initiating psychological states like depression and Read More →

    This is quick post alerting my readers to some new research about Crohn’s disease (CD). CD is an inflammatory, autoimmune bowel disease that can affect any part of the digestive tract. However, it is most likely to manifest itself in the ileum of the small intestine or proximal colon. It primarily causes abdominal Read More →

  It’s been known for quite a long time that shift workers are at an increased risk for developing a number of diseases. Observational studies have found a strong association between shift work and heart and cerebrovascular diseases. (1) Other studies have noted robust correlations between shift-work and the risk of obesity (2) (3), diabetes Read More →

  Today’s post will cover some of the research concerning the connection between gut dysbiosis and autism spectrum disorders (ASDs). ASDs are a group of developmental disabilities that cause a whole host of challenges in afflicted children. Among these are difficulties with social interaction, communication, behavior and movement. Males are approximately four times more likely Read More →

Much has been written about the harmful consequences of runaway oxidation. As part of normal cellular respiration, there is no way to avoid some level of free radical production because for better or worse, oxygen is a very reactive substance yet necessary for life itself. Oxidation, however, is not merely the addition of oxygen atoms Read More →

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