Abbreviations: CNS: central nervous system DNA: deoxyribonucleic acid DNMTs: DNA methyltranferases EAAT: excitatory amino acid transporter EAAT3: excitatory amino acid transporter 3 ENS: enteric nervous system FODMAP: Fermentable Oligo-, Di- and Mono-saccharides and Polyols GERD: gastroesophageal reflux disease GSH: glutathione IBS: irritable bowel syndrome LPSs: lipopolysaccharides SAM: S-adenosylmethionine SIFBO: small intestinal fungal and bacterial Read More →

  Today I want to continue my discussion of foods, drinks and drugs that tend to aggravate an infected and inflamed gastrointestinal mucosa. Fiber The last post covered gut bacteria’s well-known ability to produce intestinal gas by fermenting fiber. However, dietary fiber, especially insoluble fiber, has other damaging characteristics. As I’ve mentioned before, fiber swells Read More →

    In this post, I discussed how unlikely it is that normal digestion of long-chain fatty acids is the source of the pathogens initiating arterial plaque formation. If anything, I showed how protective chylomicrons are in preventing just that. This then leaves us with increased intestinal permeability as the most likely source of translocating Read More →

  In the last post I wrote about how beneficial bacteria shapes our immunity. Today I want to review some studies in children examining the association between gut dysbiosis and allergic diseases. As I’ve mentioned, commensal gut flora not only maintain the integrity of the gut wall preventing endotoxins and other antigens from entering systemic circulation, Read More →

This is the third and last post in my series on insomnia. Today I want to talk about how diet can sabotage your chances of getting a good night’s sleep. Some of what follows will be glaringly obvious, but hopefully you’ll find something here that you didn’t know before. I’ll be dividing today’s post into Read More →

  Today’s post covers how endotoxemia and a “leaky gut” negatively impact the hormonal or endocrine system known as the hypothalamic-pituitary-adrenal axis (HPA). The HPA axis is a negative-feedback circuit between the hypothalamus, the pituitary gland and the adrenals. Using hormones and the nervous system, these structures are in constant communication with one another to Read More →

“We calculate that 99.99% (by weight) of the pesticides in the American diet are chemicals that plants produce to defend themselves….We estimate that Americans eat about 1.5g of natural pesticides per person per day, which is about 10,000 times more than they eat of synthetic pesticide residues.” From the paper Dietary pesticides (99.99% all natural) Read More →

  This is the fifth post in the small intestinal bacterial overgrowth (SIBO) series. This and the next post deal with nutritional factors that predispose to SIBO. As I discussed here and here, there are a number of “non-dietary” causes of SIBO. Nevertheless, many of these diseases are clearly due to dietary factors, such as Read More →