Abbreviations: ASO mice: alpha synuclein over-expressing mice aSyn: alpha-synuclein BBB: Blood Brain Barrier IBD: Inflammatory Bowel Disease IBS: Irritable Bowel Syndrome MSA: multiple system atrophy, Shy–Drager syndrome PD: Parkinson’s Disease SCFAs: Short Chain Fatty Acids SIBO: Small Intestinal Bacterial Overgrowth   According to the Merck Manual, Parkinson’s disease (PD) is defined as: “a slowly progressive, degenerative disorder Read More →

Abbreviations: F-HFD: fructose enriched high-fat coconut oil diet F-SO-HFD: fructose enriched high-fat soybean oil diet HFD: high-fat coconut oil diet LPSs: lipopolysaccharides PUFAs: polyunsaturated fatty acids SO-HFD: high-fat soybean oil diet Viv: low-fat, high-fiber rodent diet   “Look! It’s moving. It’s sa — it’s… it’s alive. It’s alive… It’s alive, it’s moving, it’s alive! It’s Read More →

  Today’s post will cover a ground-breaking study out of Sweden that examined the interactions between gut flora and the blood-brain barrier (BBB). (1) This definition of the blood-brain barrier from Wikipedia sums up its structure and function quite nicely: “The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood Read More →

Gluten

On February 13th of 2013, I published a post entitled Fibromyalgia, Irritable Bowel Syndrome and Endotoxemia. I made the case that the high prevalence of bowel dysfunction and fibromyalgia was no mere coincidence. In today’s post, I’ll present evidence from a preliminary study out of Spain implicating non-celiac gluten sensitivity (NCGS) as a possible trigger Read More →

bigstock

  Abbreviations: BMI: body mass index FPG: fasting plasma glucose HbA1c: glycosylated hemoglobin hs-CRP: C-reactive protein IL-6: interleukin 6 IL-10: interleukin 10 IFN-y: interferon gamma LPSs: lipopolysaccharides SIFBO: small intestinal fungal and bacterial overgrowth TNF-a: tumor necrosis factor alpha Today’s post will review an interesting study out of Iran that was published in December (1). Read More →

  It’s been known for quite a long time that shift workers are at an increased risk for developing a number of diseases. Observational studies have found a strong association between shift work and heart and cerebrovascular diseases. (1) Other studies have noted robust correlations between shift-work and the risk of obesity (2) (3), diabetes Read More →

Not Just For Vampires! Those who read my small intestinal bacterial overgrowth (SIBO) series know that I credit garlic, along with probiotics and prebiotics, for helping me cure myself of it. I described my experience in the last post of that series. I’ve since received many emails from people about their experiences using this herb. Read More →

  High blood pressure or hypertension afflicts one in four adults in the developed world. Hypertension is diagnosed when sustained blood pressure reaches or exceeds 140 mm HG systolic pressure (maximum arterial pressure) over 90 mm Hg diastolic pressure (minimum arterial pressure). Hypertension is a major risk factor for heart disease and stroke and should Read More →

  What would happen if you fed prebiotics to genetically obese mice or mice fed an obesity-inducing high-fat diet? Would anything change? That’s the subject of today’s post, which covers such an experiment published in 2011. (1) Two different types of mice were used in this study. The ob/ob C57BL/6 mouse and the C57BL/6J mouse. Read More →

  Today I want to cover how gut pathogens can negatively impact the ability to digest food and regulate appetite. Here is an illustration of what should be, but oftentimes isn’t, absorbed in the digestive tract:   Your ability to absorb nutrition is reliant on a healthy small intestine. If any part of the small Read More →

  As promised, I want to discuss what role, if any, dietary fat plays in metabolic endotoxemia, especially in relation to cardiovascular disease. It appears from both animal and human studies that fat indeed increases the translocation of inflammatory lipopolysaccharides (LPS) from the gut into systemic circulation. What needs to be determined is whether all Read More →

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