Abbreviations: ASO mice: alpha synuclein over-expressing mice aSyn: alpha-synuclein BBB: Blood Brain Barrier IBD: Inflammatory Bowel Disease IBS: Irritable Bowel Syndrome MSA: multiple system atrophy, Shy–Drager syndrome PD: Parkinson’s Disease SCFAs: Short Chain Fatty Acids SIBO: Small Intestinal Bacterial Overgrowth   According to the Merck Manual, Parkinson’s disease (PD) is defined as: “a slowly progressive, degenerative disorder Read More →

“Chronic low-grade inflammation is now considered to be a critical pathological factor underlying many modern chronic diseases, including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases, and is associated with aging. Chronic low-grade inflammation is characterized by elevated circulating levels of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, and IL-6. A primary cause Read More →

Glass

  Abbreviations: CNS: central nervous system DNA: deoxyribonucleic acid DNMTs: DNA methyltranferases EAAT: excitatory amino acid transporter EAAT3: excitatory amino acid transporter 3 ENS: enteric nervous system FODMAP: Fermentable Oligo-, Di- and Mono-saccharides and Polyols GERD: gastroesophageal reflux disease GSH: glutathione IBS: irritable bowel syndrome LPSs: lipopolysaccharides SAM: S-adenosylmethionine SIFBO: small intestinal fungal and bacterial Read More →

Fresh Apple

  Today’s post will cover a question that repeatedly comes up. It’s a question I’m sure many of you also have: “What diet should I be following when dealing with a gut issue?” Let me first dispense with dietary recommendations that have not been subjected to controlled trials to assess efficacy for controlling annoying or Read More →

Coronary

  As long time readers of this blog know, I consider metabolic syndrome (insulin resistance, hypertension, cardiovascular disease, etc.) as fundamentally caused by translocating gut bacteria to the liver and systemic circulation. This explains what initiates what I’ve termed “The Inflammatory-Cortisol Ballet” and the metabolic consequences that flow from that. When it comes to heart Read More →

Colon Anatomy

  This is a short post about an intriguing study done in rodents to assess what effect different polyunsaturated fatty acids (PUFAs) have on progression of ulcerative colitis (UC). (1) Ulcerative colitis is defined by Taber’s medical dictionary as: “An inflammatory bowel disease marked pathologically by continuous inflammation of the intestinal mucosa, which typically involves Read More →

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  Over the past year and a half, I’ve spent much my time on this blog detailing the various dietary practices and other conditions that can impair intestinal-barrier function, and for good reason. While our intestines are located within us, as far as the body is concerned, this environment is actually external to it. And Read More →

  “Saturated fats are benign with regard to inflammatory effects, as are the MUFAs [monounsaturated fats]. The meager effect that saturated fats have on serum cholesterol levels when modest but adequate amounts of polyunsaturated oils are included in the diet, and the lack of any clear evidence that saturated fats are promoting any of the Read More →

  The role of stress in negatively impacting the gastrointestinal system has long been recognized. It doesn’t take an Einstein to note a strong correlation between acute psychological stress and the onset of gut feelings that are anything but pleasant. I’ve written about how gut dysbiosis is capable of initiating psychological states like depression and Read More →

  I consider bacterial translocation from the gut, aka, metabolic endotoxemia, the key to understanding chronic conditions like diabetes and cardiovascular disease. Gut pathogens and large food molecules that breach the gut wall provoke inflammatory immune responses that negatively impact the liver and other organs throughout the body, including the brain. For those of you Read More →

  Continuing with my coverage of regulatory tight-junction proteins and gut-barrier function, today I want to examine the role of a particular member of our beneficial gut flora community. A 2008 study examined which of the following gut bacteria contributed the most to gut-barrier function (1): Bifidobacterium breve Bifidobacterium infantis Bifidobacterium longum Lactobacillus acidophilus Lactobacillus delbrueckii Read More →

  Spend anytime visiting nutrition-oriented blogs and you quickly discover that the topic of dairy consumption elicits strong opinions. Dairy, in all its forms, has been variously blamed for heart disease, cancer, autism, diabetes, obesity, Kim Kardashian’s fame…well pretty much everything. Some caution against the consumption of dairy by pointing to the fact that humans Read More →

  Today I want to continue my discussion of foods, drinks and drugs that tend to aggravate an infected and inflamed gastrointestinal mucosa. Fiber The last post covered gut bacteria’s well-known ability to produce intestinal gas by fermenting fiber. However, dietary fiber, especially insoluble fiber, has other damaging characteristics. As I’ve mentioned before, fiber swells Read More →

  Today I’m going to talk about some dietary changes that may offer some of you symptom relief from your gastrointestinal issues. This is not a cure for small intestinal bacterial overgrowth or inflammatory bowel diseases like Crohn’s disease or ulcerative colitis. These disorders will require reducing gut pathogens and/or overgrowth of fungus like Candida Read More →

  As we are about to enter the festive 2012 holiday season, I thought it appropriate to blog about heart disease. Many of you may not know this, but the holiday season sees more deaths from heart attacks than any other time of the year. Merry Christmas and Happy Hanukkah y’all! (1) For those of Read More →

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