Saccharin

Today’s post is inspired by an Israeli paper published in the journal Nature that studied the effects on glucose metabolism and gut flora from ingesting three popular artificial sweeteners. What they found is of more than passing interest in this calorie-obsessed age. (1) I spend a lot of time on this website writing about the Read More →

Glass

  Abbreviations: CNS: central nervous system DNA: deoxyribonucleic acid DNMTs: DNA methyltranferases EAAT: excitatory amino acid transporter EAAT3: excitatory amino acid transporter 3 ENS: enteric nervous system FODMAP: Fermentable Oligo-, Di- and Mono-saccharides and Polyols GERD: gastroesophageal reflux disease GSH: glutathione IBS: irritable bowel syndrome LPSs: lipopolysaccharides SAM: S-adenosylmethionine SIFBO: small intestinal fungal and bacterial Read More →

Fresh Apple

  Today’s post will cover a question that repeatedly comes up. It’s a question I’m sure many of you also have: “What diet should I be following when dealing with a gut issue?” Let me first dispense with dietary recommendations that have not been subjected to controlled trials to assess efficacy for controlling annoying or Read More →

Untitled

  The metabolic consequences observed indicate that micobiota disruption during a critical development window can explain later life phenomena, including adult obesity. LDP [low-dose penicillin] may decrease particular early-life-protective bacterial populations, which is consistent with coevolution with microbes having specific interactions promoting metabolic fitness. As “keystone” species, their reduction could lead to broad intestinal ecologic Read More →

Dog-doing

  Today’s post will cover a meta-analysis (review) of randomized clinical trials that studied prebiotics and their effects on a host of different metabolic markers in humans. Published in the British Journal of Nutrition, this paper covered the results of twenty-six trials that collectively studied 831 subjects. (1) Studies included in this meta-analysis were restricted Read More →

Coyote

  Many of you are aware of the many beneficial bacterial species located within the Lactobacillus and Bifidobacterium genera. Fewer of you, however, are aware that there are also beneficial yeasts that inhabit our gastrointestinal tract. While much remains to be discovered about gut bacteria, we know even less about beneficial yeasts, although one such Read More →

Coronary

  As long time readers of this blog know, I consider metabolic syndrome (insulin resistance, hypertension, cardiovascular disease, etc.) as fundamentally caused by translocating gut bacteria to the liver and systemic circulation. This explains what initiates what I’ve termed “The Inflammatory-Cortisol Ballet” and the metabolic consequences that flow from that. When it comes to heart Read More →

capsulas

  I’ve written a lot on this blog about the many dietary practices that can make gut dysbiosis worse. However, it’s clear from the emails I get that many people trace their gastrointestinal distress to one or more courses of antibiotics. And the reason for this is that the overwhelming majority of these drugs have Read More →

Gluten

On February 13th of 2013, I published a post entitled Fibromyalgia, Irritable Bowel Syndrome and Endotoxemia. I made the case that the high prevalence of bowel dysfunction and fibromyalgia was no mere coincidence. In today’s post, I’ll present evidence from a preliminary study out of Spain implicating non-celiac gluten sensitivity (NCGS) as a possible trigger Read More →

Colon Anatomy

  This is a short post about an intriguing study done in rodents to assess what effect different polyunsaturated fatty acids (PUFAs) have on progression of ulcerative colitis (UC). (1) Ulcerative colitis is defined by Taber’s medical dictionary as: “An inflammatory bowel disease marked pathologically by continuous inflammation of the intestinal mucosa, which typically involves Read More →

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  Welcome back from your second and last intermission. I trust the wait wasn’t too long. In today’s post, I’ll be concentrating on how cortisol is regulated by the body, and how these regulatory systems are shaped by immune activation. There is a happy medium where hormone concentrations within a defined lower and upper limit Read More →

Dancer

  Welcome back from your intermission! It’s now time to begin act two of our inflammatory-cortisol ballet. In the first act we saw what happens when cortisol is low, as in adrenal insufficiency, and what occurs when cortisol is high, as in Cushing’s syndrome. But it’s now time to introduce the other members of our Read More →

This is a short post to alert you to an email I received from Anthony Colpo about his new book on whole grains. I’ve just finished reading it and highly recommend that my readers download their free copy from Amazon.com. I’ve copied Anthony’s email below, and as requested, left a five-star review on that website. Read More →

bigstock-Female

  Over the past year and a half, I’ve spent much my time on this blog detailing the various dietary practices and other conditions that can impair intestinal-barrier function, and for good reason. While our intestines are located within us, as far as the body is concerned, this environment is actually external to it. And Read More →

bigstock

  Abbreviations: BMI: body mass index FPG: fasting plasma glucose HbA1c: glycosylated hemoglobin hs-CRP: C-reactive protein IL-6: interleukin 6 IL-10: interleukin 10 IFN-y: interferon gamma LPSs: lipopolysaccharides SIFBO: small intestinal fungal and bacterial overgrowth TNF-a: tumor necrosis factor alpha Today’s post will review an interesting study out of Iran that was published in December (1). Read More →