Abbreviations: ATIs: amylase and trypsin enzyme inhibitors HFD: high-fat diet HPA axis: hypothalamic-pituitary-adrenal axis IAP: intestinal alkaline phosphatase (aka alkaline phosphatase) IL1-β: interleukin 1 beta LPSs: lipopolysaccharides NF-kB: nuclear factor kappa B PUFAs: polyunsaturated fatty acids TLRs: toll-like receptors TLR4: toll-like receptor 4 TNF-α: tumor necrosis factor alpha WGA: wheat germ agglutinin Today I Read More →

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  Abbreviations: BMI: body mass index FPG: fasting plasma glucose HbA1c: glycosylated hemoglobin hs-CRP: C-reactive protein IL-6: interleukin 6 IL-10: interleukin 10 IFN-y: interferon gamma LPSs: lipopolysaccharides SIFBO: small intestinal fungal and bacterial overgrowth TNF-a: tumor necrosis factor alpha Today’s post will review an interesting study out of Iran that was published in December (1). Read More →

  The role of stress in negatively impacting the gastrointestinal system has long been recognized. It doesn’t take an Einstein to note a strong correlation between acute psychological stress and the onset of gut feelings that are anything but pleasant. I’ve written about how gut dysbiosis is capable of initiating psychological states like depression and Read More →

  It’s been known for quite a long time that shift workers are at an increased risk for developing a number of diseases. Observational studies have found a strong association between shift work and heart and cerebrovascular diseases. (1) Other studies have noted robust correlations between shift-work and the risk of obesity (2) (3), diabetes Read More →

  Today’s post will cover a recent paper published in the journal Proceedings of the National Academy of Sciences. (1) The research group responsible for this paper has been at the forefront in investigating how metabolic endotoxemia impacts numerous health outcomes, including weight regulation and glucose control. This study sought to determine whether a particular Read More →

  I consider bacterial translocation from the gut, aka, metabolic endotoxemia, the key to understanding chronic conditions like diabetes and cardiovascular disease. Gut pathogens and large food molecules that breach the gut wall provoke inflammatory immune responses that negatively impact the liver and other organs throughout the body, including the brain. For those of you Read More →

  Spend anytime visiting nutrition-oriented blogs and you quickly discover that the topic of dairy consumption elicits strong opinions. Dairy, in all its forms, has been variously blamed for heart disease, cancer, autism, diabetes, obesity, Kim Kardashian’s fame…well pretty much everything. Some caution against the consumption of dairy by pointing to the fact that humans Read More →

  Fibromyalgia is a disease characterized by chronic wide-spread pain. These painful areas are spread throughout numerous points on the body. Other symptoms of this disorder are joint stiffness, gastrointestinal upset and mental distress: insomnia, fatigue, depression, anxiety and cognitive dysfunction. Estimates for the prevalence of fibromyalgia range from between 1% to 2% of the Read More →

  Today I want to briefly review two research papers examining the role of increased intestinal permeability (leaky gut) and visceral fat accumulation. Visceral fat, otherwise known as central obesity, is a recognized risk factor for the development of fatty liver, type 2 diabetes and cardiovascular disease. This type of fat is packed in and Read More →

  “Although genetic and biological factors play a major role in the development of obesity, hypertension, insulin resistance, and diabetes, these common disorders that are part of the metabolic syndrome are probably influenced by other factors. Evidence suggests that these disorders are mediated by a complex interplay between genetics, biology, and the environment. Stress, whether Read More →

  As promised, I want to discuss what role, if any, dietary fat plays in metabolic endotoxemia, especially in relation to cardiovascular disease. It appears from both animal and human studies that fat indeed increases the translocation of inflammatory lipopolysaccharides (LPS) from the gut into systemic circulation. What needs to be determined is whether all Read More →

  As we are about to enter the festive 2012 holiday season, I thought it appropriate to blog about heart disease. Many of you may not know this, but the holiday season sees more deaths from heart attacks than any other time of the year. Merry Christmas and Happy Hanukkah y’all! (1) For those of Read More →

  This is part two of my three-part series on insomnia. Today I want to cover how disease and inflammation cause sleep problems. In part one, I discussed some habits that help you get a good night’s sleep. And for a number of you who have occasional sleeplessness, improving your sleep hygiene is all that’s Read More →

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