I want to continue my series on weight dysregulation by examining the role endotoxemia may play.  As you may have noticed, nowhere in the title does the word obesity appear. While I will talk about how gram-negative pathogens can promote weight gain, it’s equally clear that lipopolysaccharides (LPSs) derived from these same organisms can Read More →

  As promised, I want to discuss what role, if any, dietary fat plays in metabolic endotoxemia, especially in relation to cardiovascular disease. It appears from both animal and human studies that fat indeed increases the translocation of inflammatory lipopolysaccharides (LPS) from the gut into systemic circulation. What needs to be determined is whether all Read More →

  Today’s post covers how endotoxemia and a “leaky gut” negatively impact the hormonal or endocrine system known as the hypothalamic-pituitary-adrenal axis (HPA). The HPA axis is a negative-feedback circuit between the hypothalamus, the pituitary gland and the adrenals. Using hormones and the nervous system, these structures are in constant communication with one another to Read More →