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  The metabolic consequences observed indicate that micobiota disruption during a critical development window can explain later life phenomena, including adult obesity. LDP [low-dose penicillin] may decrease particular early-life-protective bacterial populations, which is consistent with coevolution with microbes having specific interactions promoting metabolic fitness. As “keystone” species, their reduction could lead to broad intestinal ecologic Read More →

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  Abbreviations: BMI: body mass index FPG: fasting plasma glucose HbA1c: glycosylated hemoglobin hs-CRP: C-reactive protein IL-6: interleukin 6 IL-10: interleukin 10 IFN-y: interferon gamma LPSs: lipopolysaccharides SIFBO: small intestinal fungal and bacterial overgrowth TNF-a: tumor necrosis factor alpha Today’s post will review an interesting study out of Iran that was published in December (1). Read More →

  Today’s post will cover a recent paper published in the journal Proceedings of the National Academy of Sciences. (1) The research group responsible for this paper has been at the forefront in investigating how metabolic endotoxemia impacts numerous health outcomes, including weight regulation and glucose control. This study sought to determine whether a particular Read More →

  What would happen if you fed prebiotics to genetically obese mice or mice fed an obesity-inducing high-fat diet? Would anything change? That’s the subject of today’s post, which covers such an experiment published in 2011. (1) Two different types of mice were used in this study. The ob/ob C57BL/6 mouse and the C57BL/6J mouse. Read More →

  Today I want to briefly review two research papers examining the role of increased intestinal permeability (leaky gut) and visceral fat accumulation. Visceral fat, otherwise known as central obesity, is a recognized risk factor for the development of fatty liver, type 2 diabetes and cardiovascular disease. This type of fat is packed in and Read More →

  It should surprise none of you that I consider weight dysregulation one of the many manifestations of gut dysbiosis. Obesity is associated with a whole host of disorders, including type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver. Much of what I’ve written about endotoxemia also applies to obesity. This isn’t to say that Read More →

  In the previous two posts I wrote about the different types of gut flora and their physiological functions. In this post, I want to write about what can go terribly wrong when our commensal gut flora are unhappy. Let’s first define the term dysbiosis or disordered flora. I find that this term is thrown around Read More →